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Amphetamine enters presynaptic neurons by passive diffusion and through plasma membrane monoamine transporters, including the dopamine transporter (DAT) in dopaminergic neurons, the norepinephrine transporter (NET) in adrenergic neurons, and the serotonin transporter (SERT) in serotinergic neurons

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Table 1 provides a comprehensive summary of these pathways, including their key components, regulatory mechanisms, and therapeutic implications

Unfortunately, around 30% of patients do not respond to current pharmacological treatments

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