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Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile

409 Moreover, resistant CCRF-CEM cells with high QPRT activity exploit amino acid catabolism as a substitute pathway for NAD + generation

In another study, Ma, et al