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Effects of caloric or protein restriction on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in children and adults

These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (1518, 71)

S., Baek M

Nevertheless, SASP can increase mortality in mice and also cause adverse effects such as weight loss and hypothermia, regardless of the impact of intact SASP or its metabolites on the system (89)