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Moreover, Unpleasant visceral stimulation has been reported to increase the expression of c-Fos in the CeA, the emotional center 52,53

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Peroxisome proliferatoractivated receptor (PPAR), a crucial transcriptional factor, regulates FAO via controlling the transcription and translation of FAO-related enzymes (Xu et al., 2022), which could further trigger the impairment of mitochondrial structure and function ( 3 Natural products for regulating mitochondrial function 3.1 Enhancing mitochondrial biogenesis and energetics It is widely found that impaired mitochondrial biogenesis and energetics contribute to the pathogenesis of kidney diseases (Weinberg, 2011

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If your response seems disproportionately low, a medical evaluation can identify treatable contributing factors