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Unfortunately, while mechanistically distinct treatment options are available, including monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotoninnorepinephrine reuptake inhibitors (SNRIs), and atypical antidepressants (e.g., bupropion, mirtazapine), inadequate or partial response is still common in MDD treatment [13, 14, 17]

Paschetta E, et al

It is not appropriate for use outside of properly designed and ethically approved research studies

2 It is characterized by sadness, feelings of worthlessness or guilt, appetite changes, sleep problems, fatigue, loss of interest, aimless physical activities or slowed movements, thinking challenges, and worst of all, suicidal thoughts

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