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IF induces sirtuin-1 (SIRT1) expression, which enhances mitochondrial biogenesis and promotes deacetylation of autophagy-related proteins, thus facilitating the removal of damaged mitochondria and misfolded proteins [67]
TNF- exerts its biological effects through two receptors: TNFR1 and TNFR2
Figure 7 3.8 Correlation analysis among the genes, microbiota and metabolites As shown in Figure 8A, characteristic strains of the HC groups Bacteroides, HT002 and Lactobacillus demonstrate strong negative correlations with docosahexaenoic acid, n-isobutyrylglycine and taurine
This flexibility is a hallmark of metabolic health and is often impaired in individuals with obesity or insulin resistance
Potential mechanisms linking cholesterol metabolism and T2DM Lipoproteins, including LDL, very-low-density lipoprotein (VLDL), and HDL, serve as primary carriers of cholesterol and fatty acids to pancreatic -cells via the bloodstream [47]
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