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Work from David Savages group showed that PLIN1 mutations from patients with lipodystrophies, which lack the C-terminus, fail to stabilize ABHD5 on LDs, resulting in greater basal lipolysis (137) and likely explains why these patients are unable to sequester FAs into TAGs
Published Research Cited in This Guide Chang CH, Tsai WC, Hsu YM, Pang JH