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Free radicals come from normal body processes, but they also increase because of: Poor sleep Stress Alcohol and smoking Illness Medication side effects Poor nutrition Environmental pollutants When oxidative stress rises, your body must work harder to protect and repair itself

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The decision to incorporate supplements depends on clinical evaluations, the patients commitment & their understanding of melasma management

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as a result, subcutaneous injections and intranasal delivery are the predominant methods used in research, though both routes present practical challenges for routine clinical use