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Acknowledgments The authors would like to thank Aouatef Bellamine, for her help with study management and Suzanne Morris, at Concrete Medical Writing, LLC, for providing medical writing support (funded by Lonza)

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Evaluation parameters Particle characterization The prepared HSPNPs were evaluated for the particle size (PS), polydispersibility index (PDI), and surface charge (ZP)

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KPV acts directly on MC1R/MC4R receptors on macrophages and epithelial cells, reducing IL-6 and TNF- at the transcription level [7,8]