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there is no stability data for storing them pre-mixed

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It has to be noted however that gain of function may also develop in parallel with loss of function, with reactive astrocytes for example losing their ability to clear glutamate in the context of motor neurone diseases

[DOI] [PMC free article] [PubMed] [Google Scholar] 189.De Alcntara Almeida I., Dorvigny B.M., Tavares L.S., Santana L.N., Lima-Filho J.V

In addition, aberrant Ca 2+ signaling causing mitochondrial dysfunction can adversely affect neurotransmitter signaling and lead to excitation/inhibition imbalance [94, 97, 98]