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Their mechanism mimics natural cardiac hormones released in response to volume overload

Rats were assessed for fine motoric impairment with modified Irvine, Beatties and Bresnahan forelimb scale (IBB scale) that can detect recovery of both proximal and distal forelimb function including digit movements during a naturally occurring behavior that does not require extensive training or deprivation to enhance motivation (64)

Injectable routes (subcutaneous or intramuscular) are common for musculoskeletal injuries and may provide more predictable dosing

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They may look for signs of nervous system problems