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209 MnO 2 as a nanoenzyme has been illustrated to simulate SOD activity and protect cartilage from oxidative stress, 210,211 it can also modulate macrophage phenotype and reduce inflammation

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Grier SJ, Turner AS, Alvis MR

This decline in incidence has been attributed to improvements over the 20th century in modifiable risk factors for dementia, such as increased prevention and treatment of hypertension and greater educational attainment