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However, whether metformin exerts disease-modifying effects in OA through anti-oxidative mechanisms, and the molecular basis underlying these effects, remain poorly understood (Supplementary Fig

A) The dihydropyridine ring of MNAH can protonate, described by the following chemical equilibrium, protonation constant, and law of conservation of mass: B) In redox reactions MNAH can be a two-electron reducing agent as exemplified in Fig