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This controlled inflammation leads to: Increased fibroblast activity Enhanced collagen deposition Strengthening of the weakened ligaments Improved joint stability and function Unlike steroid injections, which suppress inflammation and may degrade tissue over time, prolotherapy seeks to stimulate tissue regeneration

J Clin Densitom

Some practitioners inject near injury site (local administration) versus systemic injection, though evidence for superiority of local injection limited

and Langer, R., eds., Marcel Decker (1990)

PubMed Central Exercise-Induced Expression & Exercise-Mimetic Properties In humans, exercise induces endogenous MOTS-c expression in skeletal muscle and in circulation