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The last comparison was of the concentrations of different metabolites between arginine and proline media for gdh3 / gdh3 mutant compared to those in the wild-type strain under the same conditions (comparison between gdh3 -R/ gdh3 -P and WT-R/WT-P)

Beyond gastrointestinal issues, CagriSema showed a pattern consistent with the known GLP-1 receptor agonist class

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This response promotes proper nutrient metabolism by increasing glucose utilization in insulin-dependent tissues such as muscle and adipose tissue, reducing endogenous glucose production, and enhancing glycogen synthesis