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Both PTI and ETI are involved in overlapping downstream immune responses, including activation of mitogen-activated protein kinases (MAPKs), calcium-mediated signaling, reactive oxygen species (ROS) burst, transcriptional reprograming, callose deposition, and biosynthesis of salicylic acid (SA) 2,3

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Finally, further efforts in understanding cGAS-STING signaling and autophagy pathways individually as well as their interactions will be instrumental for their targeting in cancer