Polycystic Ovarian Syndrome (PCOS) : Women with PCOS have difficulty with ovulation and if you do not ovulate, the follicles never rupture which means that the ovary is left with many small cysts that over time can become very large and painful
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Anim 2024 112 Wei W, Zeng Q, Wang Y, Guo X, Fan T, Li Y et al (2023) Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects
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However, hormonal activity (from PCOS, menopause, or other factors) can stimulate new follicles over time