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The simplified model, comprising four predictors: NIHSS at 24 hours after EVT, age, pre-stroke mRS score, and symptomatic intracranial hemorrhage, performed comparably (C statistic 0.90[0.89, 0.91])

PloS Genet (2015) 11(12)

22 Interleukin-6, vascular endothelial growth factor, insulin-like growth factor-1 and Annexin V assay kit were from Life Technologies (Carlsbad, CA, USA)

Notably, the Wnt/-catenin signalling pathway is necessary for embryonic development and adult tissue homeostasis regeneration

49 These findings suggest that inhibiting TGF 1 could promote BBB integrity via suppression of vascular permeability pathway signaling as well as by inducing factors to promote BBB vascular integrity