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A retrospective cohort study to investigate the distinct effects of antihypertensives on depression enrolled 181,709 patients and found that other antihypertensives may have a negative effect on the risk of depression compared with ARBs (216)

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Xanthine oxidase (XO), which participates in purine metabolism, is another key enzymatic source of ROS, producing both superoxide and HO during the conversion of hypoxanthine to xanthine and xanthine to uric acid 50