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We summarize key mechanisms of action, categorize clinically relevant peptide classes, and address current limitations, including gaps in human data, safety considerations, and regulatory ambiguity

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The proteins were embedded in a box of OPC water molecules (minimum distance of 12 from the solute to the boundaries of the box) and the net charge of the system was set to zero by neutralization with Cl-ions using the program tLEaP included in AmberTools21 ( 60