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Vitamin B12 is crucial in various bodily functions, particularly energy production and metabolic processes

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates MachadoJoseph disease

McMahon, S., Grondin, F., McDonald, P

Additionally, metformin inhibits M.tb growth, induces mitochondrial ROS production, promotes phagosomelysosome fusion in vitro, ameliorates pulmonary pathology, attenuates chronic inflammation, augments immunity, and improves the therapeutic effect of the standard anti-TB regimen in M.tb -infected mice

This energy impairment likely results in a hypometabolic state as the illness progresses (59, 401, 407, 413), called the cell danger response (414416)