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Most of the studies focus on the effect of NAC on cells and animal models with a notable absence of comprehensive clinical trial data which would lead to unknown biological effects and human health risks, thereby impeding its clinical application

Thus, additional investigations into the therapeutic potential of natural compounds in RA management are imperative

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reported that in breast cancer cells, Erastin significantly increased the expression of key autophagy-associated proteins, including beclin-1, ATG5, ATG12, and LC3B, while concurrently decreasing levels of the autophagy substrate p62 (50)

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