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Moreover, collateral sensitivity to tamoxifen is ROS-mediated and acts synergistically with rotenone (a ROS generating drug)

BSO treatment, which inhibits the rate limiting enzyme for GSH synthesis, resulted in almost 80% reduction in extra mitochondrial GSH concentration compared to about 50% reduction in the mitochondrial GSH pool suggesting that cytosolic GSH is more sensitive to BSO compared to mitochondrial GSH

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