"It's preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinson's Disease and Alzheimer's," said Beelman

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& Pouyssgur, J
Mixing these nutrients does not typically cause negative interactions
While they've been around for more than a century, it's only recently that people have been using them for aesthetic purposes, and there's growing concern about what people are actually putting in their bodies since they're currently unregulated