Leucine promotes cell signaling and muscle protein synthesis and has proven safe and effective in some clinical trials without adverse effects.14 Leucine supplementation in the elderly may even help improve muscle mass by providing anabolic stimuli to muscles
That selectivity is what makes it attractive for protocols where minimizing hormonal disruption is the priority
For instance, SCFAs can inhibit NF-B activation and the secretion of inflammatory cytokines like TNF- in peripheral blood monocytes, neutrophils, and macrophages, thereby mitigating excessive immune responses
J Microbiol Immunol Infect 58(1):6269 Vinelli V, Biscotti P, Martini D, Del Bo C, Marino M, Meroo T et al (2022) Effects of dietary fibers on Short-Chain fatty acids and gut microbiota composition in healthy adults: A systematic review
This may contribute to reduced pain and improved motor function following nerve injuries