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Despite the limitations of real-world observational studiesincluding the absence of randomization, control for confounding variables, and inability to establish causalityresearches offer confidence regarding the pancreatic safety profiles of GLP-1 RAs [55,61]

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The study from SLE patients showed an increase expression of Fas/Fas ligand and caspase-3 activity in T cells with a consequent increase in T lymphocyte apoptosis [50,108]

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