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PI3K/Akt/mTOR Signaling Cascade A primary downstream pathway of IGF-1R activation is the PI3K/Akt/mTOR cascade, which regulates cell survival, protein synthesis, and metabolic homeostasis

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Moreover, GA has been shown to mitigate liver damage in rats exposed to dust, significantly reducing the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), and altering the serum triglyceride (TG) levels, similar to the protective effects observed with PM2.5 exposure

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