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Sirtuin 7 regulates nitric oxide production and apoptosis to promote mycobacterial clearance in macrophages

They help reduce excessive swelling and pain while maintaining the controlled inflammation necessary for proper tissue repair

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16 weeks of dosing were used with up-titration every second week to reach different maintenance doses of twelve (2.4 mg), eight (4.8 mg) and six (9.0 mg) weeks, respectively