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Smolders LA, Meij BP, Onis D, Riemers FM, Bergknut N, Wubbolts R, Grinwis GC, Houweling M, Groot Koerkamp MJ, van Leenen D, Holstege FC, Hazewinkel HA, Creemers LB, Penning LC, Tryfonidou MA: Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Li et al., 2018

The water trickles down the side of the vial as the plunger is released slowly

Research indicates that interactions within the HGF system may initiate downstream signaling pathways, including kinase-mediated cellular responses and intracellular messenger activation

Weekly injections are the standard recommendation for the first phase of treatment