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Cytotoxicity assays are often set up in parallel samples

J., Bucknall, R

As previously established, the liver relies heavily on glutathione conjugation (via Glutathione S-Transferases) to neutralize and excrete toxic intermediates, including excess inflammatory mediators and circulating histamine

doi: 10.1016/j.mib.2019.05.008 340 Rivero-MenendezO.Soto-DebranJ

It is accepted that an excessive burden of ROS may lead to abnormal cell growth, corresponding changes in intracellular homeostasis and damage to important components of in the cell when the antioxidant defense and/or DNA repair mechanisms cannot balance the excess oxidants [29]