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Without the BBB, the CNS is at risk of invasion of toxins, pathogens, immune cells, or ion dysregulation, which would lead to neuronal dysfunction and degeneration [1]

Jul 2024;398:105-117

This unique mechanism gives cagrilintide a distinct role in weight loss regimens, especially when combined with GLP-1 receptor agonists

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however, excessive dosing may result in exaggerated pharmacological effects