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doi: 10.1016/j.jbspin.2025.105892 Summary Keywords NLRP3 inflammasome, oxidative stress, programmed cell death, sodium urate crystal, soluble uric acid Citation Yang Q, Xu Y, Zhang J, Xiao N, Lu H, Chen B, Yang B, Xie Z and Li Z (2026) From soluble uric acid to sodium urate crystal: immune metabolic inflammation driven by uric acid morphological transformation and mechanism-oriented therapy