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effect may be limited

A randomized, placebo-controlled trial involving patients with metabolic syndrome found that supplementing with just 300 mg/day of ALA for four weeks improved flow-mediated vasodilation (FMD) by a staggering 44%

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10.1038/s41572-020-0187-8 [DOI] [PubMed] 55.Vidal-Alaball J, Butler CC, Potter CC (2006) Comparing costs of intramuscular and oral vitamin B12 administration in primary care: a cost-minimization analysis

Moreover, in breast cancer, IGF-1 mainly upregulates cysteine-rich 61 (Cyr61) by activating the PI3K/AKT pathway and an increase in Cyr61 promotes the growth and invasion of breast cancer cells (27)