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More research is needed to validate their potential benefits

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In addition, metabolites can be administered with easily controlled pharmacokinetics, thereby reducing the risk of immune reactions associated with drugs

No prospective studies have been conducted in humans in controlled circumstances to demonstrate whether CYP450 polymorphisms lead to an increase or a decrease in paracetamol oxidation nor have there been studies demonstrating that CYP450 polymorphisms in humans increase or decrease the risk of paracetamol toxicity before or after an overdose

References 1 JinNGeorgeTLOttersonGAVerschraegenCWenHCarboneDet al