Formulated with Acyl-Glutathione, a master antioxidant comprising three amino acids that replenishes fragile skin and reduces wrinkles, plus a Vitamin F Blend containing flax, chia, and macadamia seed oils to restore suppleness
Advances in Peptide Research, 22 (3), 121-134
doi: 10.1038/ncomms3081
Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)
Genes encoding membrane transporters are also critical to the normal responses of -cells to glucose metabolism including KCNJ8 (K ir 6.1), KCNJ11 (K ir 6.2), KCNQ1 (K v 7.1), SLC39A11 (zinc transporter), SLC30A8, and SLC22A18