Despite this, NAC administration increases GSH levels in rats [112, 113] and humans [114]
It is recognized for its stability and high resistance to enzymatic degradation, making it a valuable compound for controlled laboratory investigation
Neuroinflammation is characterized by the activation of microglia and reactive astrocytes in the brain, as well as the production of inflammatory mediators such as cytokines (TNF-, IL-1, and IL-6), chemokines, complement cascade proteins, reactive oxygen species, and reactive nitrogen species (RNS)
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Another challenge is that redox status fluctuates over time both between individuals and within the same patient, influenced by factors, such as nutrition, lifestyle, environmental exposures, and underlying medical conditions