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3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)

The official prescribing information for Mounjaro suggests that women using oral contraceptives should switch to a non-oral method or add a barrier method for four weeks after starting the medication and for four weeks after each dose escalation

Its use during pregnancy and breastfeeding is not recommended

Moreover, studies have shown that an ACL reconstruction will be biomechanically inferior to a normal knee if a significant ramp lesion is present but not repaired

& Imlay, J.A