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In individuals with pre-existing gastrointestinal conditions such as inflammatory bowel disease, coeliac disease, or irritable bowel syndrome, introducing any new supplement may temporarily affect bowel habits as the digestive system adapts

Cao M, Ou Z, Sheng R, et al

Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens

For sensitive skin, the Beauty Time team recommends starting with once daily use and then gradually increasing use to avoid any irritation

Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome