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Chronic hyperglycemia initiates a cascade of molecular eventsincluding the accumulation of advanced glycation end products (AGEs), activation of the polyol pathway, enhanced protein kinase C (PKC) signaling, and mitochondrial dysfunctionculminating in glomerular hyperfiltration, podocyte injury, and progressive glomerular and tubulointerstitial fibrosis

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Springer, 39-51, 2013

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A similar deviation from a uniform relationship between neutralization and protection has been described for nAbs to influenza virus 13 and for a combination of SARS-CoV-2 nAbs 14

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Graphical Abstract Similar content being viewed by others Introduction Retinitis pigmentosa (RP) is a genetic disorder affecting approximately 1 in 4,000 individuals that leads to loss of photoreceptors and decrease in visual acuity [1, 2]

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