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This clarification step is crucial to prevent clogging of the affinity column and to enhance the efficiency of the purification process

In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

Mechanisms of Central Nervous System Modulation 3.1

Med Hypotheses (2020) 144:110055

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