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It is also advised to avoid mega doses of pyridoxine in pregnant or breastfeeding patients unless necessary, since safety data for doses beyond the recommended dietary allowance are limited

Medical Progress October 1980 Vitamin B(12), folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation

A comprehensive review in Nature Reviews Disease Primers described B12 deficiency as a significant and underrecognized public health concern, particularly among older adults, individuals with gastrointestinal conditions, and those following plant-based diets (Green et al., Nat Rev Dis Primers , 2017)

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Adequate folic acid intakes can normalize high homocysteine levels via increased remethylation of homocysteine to methionine via 5-methyltetrahydrofolate-homocysteine methyltransferase (a.k.a