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This figure, drawn from the original plasma studies following GHK-Cus identification, has become the standard reference point in the literature whenever researchers discuss the peptides relationship to aging

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1b), exhibit strong affinity to Met with dissociation constants ( K D ) ranging from a few to 20 nM

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Essentially, two groups can be distinguished: (i) molecules containing GSH or GSH-like moiety and (ii) molecules whose enzymatic activation occurs through a GSH-conjugate intermediate 109