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The incorporation of various unnatural amino acid residues into peptides was proven to be a very productive methodology

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Starting at lower frequency and concentration, then gradually increasing, prevents this problem almost entirely

VPA treatment in rat cerebral cortex induced differentiation and reduced the proliferation of neural progenitor cells via activation of ERK-P21 Cip/WAFI pathway mediated by -catenin pathway (Jung et al., 2008)

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