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In the context of AD, CR or intermittent fasting independently has been shown to promote cognitive function and protect from worsening AD pathology in animal models of AD 4,5,6,7,8,45,46,52,53

However, keeping an elevated intracellular ROS level within AML cells without altering their viability and proliferation potential requires the establishment of a set of detoxification mechanisms to support their continued growth [33]

It is conceivable that when GCL is induced tremendously, the step catalyzed by GS may become limiting

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a, b , Immunoblot analysis of Huh7, Hep3B and H1299 cells treated with Rapamycin (50 nM) or Torin1 (250 nM) for 6 h ( a ) or 72 h ( b )