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Here, we find that LDHB promotes GSH synthesis and defends against ferroptosis by upregulating SLC7A11, the functional subunit of the cystine/glutamate antiporter system Xc (SLC7A11 and SLC3A2), which takes up extracellular cystine to synthesize the antiferroptotic metabolite GSH [36, 63], a cofactor of GPX4 that neutralizes lipid peroxides and suppresses ferroptosis [33]

Glutathione is undoubtedly beneficial for the kidneys with minimal downsides

Repetitive computer work, manual labor, cooking, gardening, and countless other activities can trigger the same degenerative process in these tendons

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