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Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

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The progressive development of fibrosis and loss of pancreatic tissue with loss of ductal secretory patency results in acute inflammation involving intra-pancreatic nerves contributing to an abdominal pain that is both incapacitating and intense

Similarly, GSH concentrations in arterial cord blood was not significantly higher in the NAC than in the placebo group (median NAC: 497 mol/L vs