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Administration of butyrate-producing bacteria (e.g., Faecalibacterium prausnitzii , Ruminococcus , Roseburia ) has been shown to upregulate GPX4 and SLC7A11 in intestinal epithelial cells ( Faecalibacterium , Blautia , and Bifidobacterium during critical illness ( Lactobacillus and Bifidobacterium strains have been reported to enhance antioxidant capacity and reduce inflammation in animal models of sepsis ( However, clinical studies evaluating microbiome-targeted interventions in critically ill patients have yielded inconsistent results

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