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Introduction Herpes simplex virus 1 (HSV-1), a member of the family Herpesviridae, subfamily Alphaherpesvirinae, is an enveloped virus with a double-stranded (ds) DNA genome consisting of a non-spherical capsid, cortex, and capsule (Whitley and Roizman, Antimicrobial peptides have received increasing attention from the scientific community over the last 20 years due to the worldwide increase in antibiotic resistance among microorganisms

Measurement of IGF-1 is complicated, by both the biology of IGF-1 and the recent need to differentiate the endogenous form of IGF-1, and the synthetic therapeutic forms developed to treat growth disorders

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In addition, HIV-1 Tat inhibits autophagy and proteasomal degradation in microglia and astrocytes, which in turn modulates EV biogenesis pathways and may amplify intercellular propagation of inflammatory signals [58, 59]