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Its broad activity across multiple transporter classes continues to support research into monoaminergic signaling and transporter pharmacology.

For example, ADH1B and ALDH2 gene variants are common in 30-50% of East Asians, influencing faster or slower alcohol metabolism and acetaldehyde clearance, but are rare in Europeans and Africans (99)

doi: 10.1016/j.yexcr.2017.05.019 221 LaughnerETaghaviPChilesKMahonPCSemenzaGL

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Notably, higher body mass index (BMI) has been linked to a lower risk of depression among older adults, which contrasts with observations in younger populations