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For the study, Wyvell and Berridge designed an experiment with rats that eliminated several alternative explanations, such as withdrawal symptoms, learned habits or drug pleasure, for the increase in compulsive drug-seeking that is commonly triggered in human addicts by encounters with drug cues

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PMID: 37

Tobacco was largely responsible for transforming the southern colonies from a subsistence to an agrarian economy, allowing the colonies to become self-sufficient and economically competitive with international rivals

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